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KMID : 0379520120280010051
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한국독성학회지
2012 Volume.28 No. 1 p.51 ~ p.56
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The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application
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Kim Dong-Ha
Lim Yun-Young
Kim Hyeong-Min
Kim So-Young
Kim Beom-Joon
Park Sung-Gil
Lee Tae-hoon
Cho Soo-Muk
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Abstract
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A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-NH2 on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-NH2 in HaCaT cells and B16F10 cells. SFKLRY-NH2 induced no skin irritation at low concentration (10 μM), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-NH2 in clinical use.
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KEYWORD
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PS-SPCL, Safety, Skin irritation test, SFKLRY-NH2, W3 peptide
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